EFSUMB - European Federation of Societies for Ultrasound in Medicine and Biology
   Case of the Month
  < Go Back to Previous Page


The Cases of the month (CoM) have been introduced by Christoph F. Dietrich as first Editor from 2008 to 2009 followed by Paul S. Sidhu from 2010 to 2015, with Maija Radzina taking over in 2016. The earliest case of the month went online in March 2008. The Publication Committee envisaged regular contributions to include artefact of the month, tip of the month in addition to cases that would be of interest. Topics have ranged from Focal liver lesions (FLL), Crohn's disease, Echoscopy, to a rare double gallbladder. All these cases are listed on the EFSUMB website under Case Archive

The translations into fourteen foreign languages can all be accessed from this page with all cases now translated into Chinese.

The Case of the Month continues to be the most viewed item on the EFSUMB website, with as many as 161,471 hits in the last four months of which 94% viewed the English version and other viewing the Latvian, Russian, Chinese and Italian translations.

If you would like to translate any of the cases please contact Maija Radzina or if you wish to submit a Case of the Month resource to EFSUMB for consideration email:

MAIJA RADZINA - Case of the Month Editor

COTM Submission Template
Click HERE
  < Go Back to Previous Page
Upcoming Events
Sign Up to Receive the EFSUMB Newsletter
Case of the Month - JANUARY (German Translation available)
A rare tumor in the gallbladder mimicking sludge

Author and correspondence:
Dr. Klaus Dirks
Department for General Internal Medicine and Gastroenterology
Interdisciplinary Sonography Center
Rems-Murr-Klinikum Winnenden gGmbH
Am Jakobsweg 1
D-71364 Winnenden, Germany
Phone: +49 (7195) 591-39322
Mail: Klaus.Dirks@rems-murr-kliniken.de

German provided by M. Radzina

Case report
A 61 year old man was admitted to our hospital due to acute GI-bleeding. The man had been completely healthy until than and did not need any medications. One year ago a small melanoma on the head had been removed in toto. Routine ultrasonography before endoscopy showed echogenic material in the gallbladder (Fig. 1 + 2, Video 1). First gallbladder sludge was suspected. Because of its inhomogeneity in an additional linear array examination and a Doppler examination performed. Here arterial vessels in the gallbladder lumen were detected, thereby proving solid tissue (Video 2).
In addition, a contrast study (CEUS) was performed: This showed multiple polypoid tumors in the gallbladder lumen with strong contrast enhancement in the arterial phase and rapid washout (Fig. 3 + Video 3). Thus the echos in the gallbladder were no sludge but an intraluminal tumor! Only CEUS revealed the extend of tumor masses filling nearly the complete gallbladder.
Unfortunately, the following endoscopy revealed multiple metastases in the stomach, duodenum and colon (Fig. 4-6) that endoscopically and histologically confirmed as metastasis of a malignant melanoma.


Malign gallbladder polyps fortunately are a rare event. Even less common than than gallbladder cancer are metastases within the gallbladder or in the gallbladder wall. Melanoma metastases can be found in nearly every human organ, even in the gallbladder. This case demonstrates melanoma metastases in the gallbladder as well as in the GI tract. Both show a polypoid tumor growth originating from the mucosa.
Echogenic material in the gallbladder lumen mostly is caused by thickened bile: “sludge”. Clumped together sludge may imitate gallbladder polyps. Vice versa polypoid tumors can imitate sludge, especially in cases of hasty US examination. In any case of doubts you should use high-frequency linear probe, examination in left side position und color Doppler. Vessels in the lesion prove a neoplastic polyp witch may be benign or malign.

As shown in this case CEUS is even more sensitive in detecting tumor vascularization. CEUS in case of doubt is an excellent and reliable tool to distinguish between tumor tissue, sludge and concrements.

1) Ettahri H, Elomrani F, Elkabous M, Rimani M, Boutayeb S, Mrabti H, Errihani H. Duodenal and gallbladder metastasis of regressive melanoma: a case report and review of the literature. J Gastrointest Oncol. 2015 Oct;6(5):E77-81.
2) Barretta ML, Catalano O, Setola SV, Granata V, Marone U, D'Errico Gallipoli A. Gallbladder metastasis: spectrum of imaging findings. Abdom Imaging. 2011 Dec;36(6):729-34.
3) Giannini I, Cutrignelli DA, Resta L, Gentile A, Vincenti L. Metastatic melanoma of the gallbladder: report of two cases and a review of the literature. Clin Exp Med. 2015 May 1-6.

1) Fig.1: Gallbladder of the patient filled with echogenic material. There are no stones detectable and no gallbladder wall thickening. At the first view (curved array) it might be only sludge in gallbladder.
2) Fig.2: Second look using the linear array: Note the inhomogeneity of the echos in the lumen. Left side position does not cause any changes. Also note the well preserved wall of the gallbladder.
3) Fig. 3: CEUS (arterial phase 13 sec after bolus injection): powerful arterial contrast enhancement in multiple polypoid lesions in the lumen of the gallbladder. This proves neoplastic tissue and rules out simple sludge.
4) Fig. 4: Polypoid melanoma metastasis in the duodenum. Note central depression as a sign of malignancy. The neighboring mucosa is completely preserved as well as the neighboring gallbladder wall in figure 1-3.
5) Fig. 5: Polypoid melanoma metastasis in the stomach. Typical black color.
6) Fig. 6: Polypoid melanoma metastasis in the colon. Typical black color.

1) Video 1: Gallbladder of the patient filled with echogenic material. There are no stones detectable and no gallbladder wall thickening. At the first view (curved array) it might be only sludge in gallbladder.

2) Video 2: Second look using the linear array and Doppler: Using low PRF several arterial branches inside the gallbladder can be detected. Note the inhomogeneity of the echos in the lumen.


Video 3: Several polyps (= melanoma metastases) within the gallbladder with marked arterial contrast enhancement. Sludge, hematoma or other avital material could definitively be excluded. 





About EFSUMB Atlas Case of the Month   Courses & Congresses Educational Publications Safety
Officers and Committees     
Member Societies
Cookies Policy

CEUS Liver
CEUS Non-Liver   
Latest Case
Case Archive
Submission Template
Euroson Congresses
Euroson Schools
Endorsed Courses
Postgraduate web course  
Exam Technique Videos
Scientific Corner
Guidelines &

EFSUMB Course Book
Course Book Student
Case of the Month
EFSUMB Verified
Training Portal

Visit out Facebook Page Visit our Facebook page >>>

© EFSUMB 2013, All rights reserved - Click here for Intellectual Property Rights